Effect of chloramphenicol and thiamphenicol on the in vitro colony-forming cell.
نویسندگان
چکیده
The effect of chloramphenicol and a proliferation. The inhibition appears to be chloramphenicol analog, thiamphenicol, reversible within a 24-hr period of cellon the growth of bone marrow colonydrug contact. In addition to their effect on forming cells in agar was investigated. At CFC proliferation, CAP and TAP appear to concentrations within therapeutic range, influence the type of CFC differentiation both drugs cause a marked reduction in resulting in predominance of macrophage the number of colonies and in the size of colonies. aggregates, indicating suppressed cellular
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Annulate lamellae in erythroblasts in the mice splenic colonies.
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متن کاملThe European Agency for the Evaluation of Medicinal Products Veterinary Medicines Evaluation Unit
a) Thiamphenicol chemical structure differs from that of chloramphenicol in having a sulpho-group instead of a nitro-group; consequently the two compounds have different metabolic pathways. In fact thiamphenicol, unlike chloramphenicol, is not an optimal substrate for the hepatic microsomal enzyme glucuronyl transferase and therefore more than 95% of the administered dose is excreted unchanged ...
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عنوان ژورنال:
- Blood
دوره 43 3 شماره
صفحات -
تاریخ انتشار 1974